Breed Health Coordinator: Wendy Tobijanski
This is now completed for Cesky Terriers, below is the last email from the AHT.
As you already know, we selected a Cesky Terrier with Scottie Cramp to be whole genome sequenced as part of Give a Dog a Genome (GDG). The sequencing has now been completed by the external laboratory and the data has been made available for us to download.
What happens next?
The amount of data generated for each sample is enormous, around 80-90 Gb. To put that into perspective, data from only 10 dogs will fill up the average modern personal computer, and the processing of the data will use the full capacity of the computer for months. As a result it takes time (about 1 week) and a great deal of computing power to download and process the data so that it is ready for analysis. Once we have completed this stage the Cesky Terrier Scottie Cramp data will be ready for further analysis.
The data will be added to the genome bank, and will begin contributing to studies in other breeds immediately. In addition, the data will be made available to other scientists for use in their own studies, and your breed has therefore made a vital contribution to genetic research affecting the welfare of dogs worldwide.
As Prof Hannes Lohi from the University of Helsinki is already working on Cesky Terrier with Scottie Cramp, we feel that the best use of the data is to share it with Prof Lohi to add to their existing data. Analysis of the data to attempt to identify any variants that contribute to Scottie Cramp in Cesky Terrier will therefore not be conducted by the GDG team at the AHT. However, we do expect that Prof Lohi will inform is of any relevant findings, which we will pass on to you.
You will continue to receive any general GDG updates, but apart from that we will contact you only if there is something specific to the Cesky Terrier to report. If you don’t hear from us, it means that Prof Lohi’s team are still in the analysis stage and have not found anything of significance.
I would once again like to thank you and the breed community for participating in Give a Dog a Genome.
I have emailed Prof Lohi to request to be kept upto date on any findings but haven’t had any response, i am in touch with Mia Puisto who is my counterpart in Finland who originally told me about Prof Lohis work and I passed this onto the AHT.
The Kennel Club have published the Co-efficiency of Inbreeding figures for 2017, Cesky Terriers are at 15.1%, up slightly from last year which was 14.8%.
To put this into perspective a COI of 12.5% would equate to the genetic equivalent of a dog produced from a grandfather to granddaughter mating.25% would equate to the genetic equivalent of a dog produced from a father to daughter mating.
Although this isn’t good we must remember that because we only have a few litters born each year it only takes one litter with a higher COI to bring the average up. We do need to be careful when breeding and to look for diversity whenever possible doing things like not inbreeding and avoiding over using the same sire as popular sire syndrome is often a big problem leading to the demise of genetic diversity in a numerically small breed.
There were 36 CT born last year, up from 2016 which was 30.
Perhaps we should use the Health Fund money to look into subsidizing DNA profiling.
3.Kennel Club health report
This was completed in September
4. I attended the Breed Health Coordinators Symposium in october. Below is the programme for the day.
Seminar One: Breed Health Conservation Plans (BHCP)
Dr Katy Evans (Health Research Manager, The Kennel Club)
The Breed Health and Conservation Plans (BHCP) aim to enable the identification of
the most significant issues in each breed, where further research and support is
required and the allocation of resources to these. These will be made in collaboration
with relevant stakeholders, including breed clubs, researchers and Breed Health
Coordinators to create bespoke plans for each breed. A further 50 breeds are
currently being identified to have BHCPs developed with them once the initial 17 are
complete; in time all breeds will have their own BHCP and these will continue to be
reviewed going forward.
Seminar Two: Epilepsy
Professor Holger Volk (Royal Veterinary College)
Seminar Three: Sniffing out the science: How to interpret information about
Dr Zoe Belshaw (Centre for Evidence-based Veterinary Medicine, University of
seminar 4,Give a dog a genome update.
Dr Cathryn Mellersh, Head of Kennel Club Genetics Centre (Animal Health Trust)
Dr Louise Burmeister, Postdoctoral Research Scientist (Animal Health Trust)
International Partnership For Dogs (IPFD) update
Dr Brenda Bonnett, CEO (International Partnership for Dogs)
Question and Answer Session with Speakers
Question and Answer Booths Dr Cathryn Mellersh & Dr Louise Burmeister (AHT) Dr Brenda Bonnet (IPFD) Dr Katy Evans & Tom Lewis (BHCP and genetic enquiries)Bonnie Wiles (Breed Watch enquiries)Dr Zoe Belshaw (Centre for Evidence-based Veterinary Medicine, University of Nottingham) BHC Mentors Dr Dan O’Neill (Vet Compass)
If anyone wants to know more about any of the seminars please ask.
I have also attended a seminar on gait and movement by Karl Jones BSc (HONS) MSc (vet physio) MCSP HCPC ACPAT chartered physiotherapist.
Do we need to do another health survey? The last one was in 2014.
I do update the health database as i receive info, but i do need people to send me the info on their dogs as their health changes, I often hear about dogs dying and then I will ask people ( as diplomatically as possible!) what they died of and can I add this info to the database, I find pet owners most helpful often going into great detail but they generally only own 1 or 2 Ceskys so it is important for you reading this to send me health info. the more information we have the better equipped we are to monitor health and spot any emerging problems quickly.